The Zofran (ondansetron) drug labels already contain information about the potential for QT prolongation. The labels are being revised to include a warning to avoid use in patients with congenital. Zofran also was commonly prescribed to pregnant women who were having problems with morning sickness. Over time, it was discovered that Zofran could have been the cause of birth defects , especially when used in the critical first trimester of pregnancy. If you are pregnant and have taken ondansetron or Zofran® during pregnancy, I want to reassure you that it likely has not affected your baby. Even if the increased risk for cleft palate or heart defects turns out to be true, the risk to your baby is still very, very small. If you or a loved one took Zofran for morning sickness during pregnancy and if your baby was born with a cleft palate or congenital heart defect, please contact us by submitting the form at right, or by calling us at 877-978-0169 for a confidential evaluation of your potential claim. I am taking zofran and it's perfectly safe and a class b drug. The ads on tv are just lawyers trying to get money for a case they can't prove. The birth defects they state are the most common among all babies born no matter a family history or not. Zofran and Pregnancy Home Zofran and Pregnancy Zofran is an anti-nausea medication that’s currently only approved for use by cancer patients undergoing chemotherapy and other treatments that cause side effects such as nausea and vomiting. Zofran has been used off-label to treat nausea and vomiting in pregnancy. The FDA warns against Zofran use in pregnancy based on recent studies regarding the association between Zofran use in early pregnancy and congenital cardiac malformations and oral clefts (cleft lip and palate). Even worse, since morning sickness is most often associated with the first trimester of pregnancy, women prescribed Zofran are taking it during an infant’s most crucial development period. It’s important to note that despite its potential risks, the FDA has not stopped Zofran from being prescribed. The bottom line on Zofran is that you and your doctor need to discuss whether it’s a good idea for you to take it to relieve your pregnancy problems. It comes down to how comfortable you are taking the medication, and how confident your doctor is prescribing it to you while keeping your health and the health of your baby a priority. Zofran (ondansetron) is an antiemetic medication used to treat nausea and vomiting due to cancer treatment and surgery. Its use as an off-label treatment for morning sickness during pregnancy has been controversial and may lead to a risk of birth defects.